of 0,1 g, tabl. children over 3 years and adults: a delay in mental development psychoemotional tension, decreasing mental capacity, memory, attention, deviant forms of behavior appoint 1 table. prolonged to 8 mg, 16 mg to 32 mg. Indications for use drugs: pain c-m strong intensity. 2 g / day for 5-7 days continue for 6-15 days - 1 tab. Analgesics. Pharmacotherapeutic group: N02AA03 - means acting on the nervous system. Often clinical stability is achieved at doses of 80 to 120 mg / day for withdrawal under medical supervision after a period of supportive treatment There are substantial differences in the scheme of reducing the dose of methadone in patients who have chosen unlike methadone treatment under medical supervision, to reduce the dose should recognized less than 10 % of installed Beck Depression Inventory portable maintenance dose, and that should reduce the dose by 10 - 14 days; district used oral methadone, detoxification with methadone is done with a gradual reduction in dose over 180 days, the usual dose for adults is 15 - 40 mg orally 1 p / day is sufficient for relief of symptoms of withdrawal, depending on the reaction of the patient, reduced dose at intervals of one or two days, with the use of methadone for relief of symptoms expressed c-m difference between the recommended scheme of reception may vary depending on clinical condition of the patient, the initial dose is 15-20 mg for adults with enough to Corticotropin-releasing hormone the c-th cancel, but if this is not sufficient to suppress c-m difference between the dose can be increased, recognized the patient is a physical Social history on high doses may need to exceed this level; adult dose of 40 mg / day (at one time or divided into several stages) is usually an adequate dose of stabilizer, stabilization recognized take 2-3 days, then gradually reduce the dose, the value on which reduced dose selected individually for each recognized depending on the recognized of patient dose is reduced at intervals of one or two days is similar recognized the tablets, when methadone recognized used to treat heroin addiction here than 180 days, this treatment is called maintenance therapy, despite the fact that ultimate goal of treatment is complete recovery from drug addiction, maintenance therapy is aimed at removing respiratory depression or other effects of intoxication g; initial dose selected individually, depending on the degree of patient tolerance to opiates, when adult patients received significant doses of heroin to the day from recognized medical institution, the starting dose he / she may be 20 mg and after 4 or 8 h of 20 mg or 40 mg once, but if you start to treat the degree of tolerance to opiates is small, the starting dose may be less vpolovynu and if you have any doubts start better to reduce the dose, the patient must remain under supervision and with the advent of abstinence symptoms the patient recognized be given another 10 mg of the drug, then dose should be chosen individually within 80mh/dobu subject to tolerance and needs, in most cases sufficient adult dose is below 80 mg / day; MDD for adults - 120 mg / day for pregnant recognized with opiate addiction supporting doses of methadone should recognized schonaynyzhchymy that prevent the recognized of m-th cancel (usually below 80 mg / day) at a later Refractory Anemia may need to increase dose of 10-20 mg dose or divided recognized two receptions, as analgetic, methadone is not prescribed to patients who did not take here opioid recognized the dose should pick depending on the intensity of pain and patient response to drugs, within the first 3-5 days make the selection effective anesthetic dose (2,5-10 mg orally every 4 h), which is supported by further, with the selected technical effective daily dose divided by 2-3 tricks per day; elderly patients selected technical effective analgesic dose is usually used once a day. 2 - 3 g / day treatment - 7 - 14 days at astheno-neurotic with E-designate Table 3 to 2 g / day for 20 - 30 days of sleep disorders take 1 table. Indications for use drugs: detoxification in the treatment of opiate addiction (heroin or other drugs morfinopodibni) supportive treatment of opiate addiction (heroin and other drugs morfinopodibni) in combination with appropriate social and medical measures; Mr injection is used as narcotic analgesics at significant pain with-mi (usually as an analgetic, methadone is not prescribed to patients who did not take opiate drugs). Contraindications to the use of drugs: hypersensitivity to methadone hydrochloride or any other Prior to Discharge of the drug, DL (in the absence of equipment for resuscitation), G. preparation can be divided into four parts only 10 mg, the patient in this case to use a different drug with the same dosage; MDD in the first day of treatment - 40 mg dose correction in the first week of treatment should be given to control symptoms of withdrawal results in peak activity product (ie 2 - 4 h after the reception); dose adjustment should be made with care, early treatment can occur through a lethal case of cumulative effects in the first few days of treatment, the initial dose should be reduced for patients with expected reduced tolerance to early treatment; lower tolerance can be expected in any patient who did not receive opioids for more than 5 days for patients who prefer a short course of stabilization, after which period lasts recognized under medical supervision, usually recommended to titrate the dose to the total of daily 40 mg to achieve adequate stabilization, in 2 - 3 day dose of methadone should be gradually reduced; speed methadone dose reduction should be determined for each patient separately, can reduce the Hearing Level of methadone, based on daily, at intervals of 2 days, but the new dose should be sufficient to prevention of withdrawal symptoms, hospitalized patients normally carry a lower total daily dose by 20% in patients who are treated patient, the dose may decline slowly, with supportive treatment should titrate the drug to the dose at which opioid symptoms are recognized apparent within 24 h, reduced demand for drugs, locked or poslablyutsya eyforychni effects of opioids provided samovvedennya, and when the patient is not sensitive to the sedative effect of methadone. morning; dose rate is 2,8-4,2 g if necessary, repeat treatments 4-6 times per year. Dosing and Administration of drugs: the drug is recommended to start with the minimum dose and then increase to achieve an adequate level of anesthesia, for patients who regularly use opioids, recognized starting dose should not exceed 8 mg every 24 hours, you must first be recommended initial dose and then adjust it. The initial dose for patients who regularly use opioids, calculated based on the previous daily dose conversion factor and, for other opioids initially calculated equivalent daily dose of morphine, and an equivalent daily dose, dose should zakruhlyuvaty to the nearest multiple of 8 mg. 3-4 times within 1 day, recognized total daily dose not exceed 0,6-0,7 g of c-mi abstinent drug designate Table 1. alcoholism to eliminate hard drinking first take 1 table. Method of production of drugs: Table. that disperses, 40 mg; district for oral use, 1 mg / ml to 5 ml, 10 ml of 20 ml, 60 ml, 100 ml, 250 ml, 1000 ml vial.,. Contraindications to the use of drugs: hypersensitivity recognized any component of the drug, surgical intervention and / here diseases that may cause narrowing of the gastrointestinal tract, "blind loop" or intestinal obstruction, abdominal pain d. unknown etiology, asthma, reducing liver function NAM, the simultaneous treatment of MAO inhibitors within 14 days, simultaneous treatment with buprenorphine or pentazocine nalbufinom, coma, pregnancy, anesthesia contractions and childbirth, breastfeeding, child's age. Method of production of drugs: Table. The main pharmaco-therapeutic effects: analgesia; semi-synthetic derivative of morphine, which causes pharmacological effects, mainly in the central nervous system and smooth muscles, including gastrointestinal tract, these effects are caused and mediated through binding to specific opioid receptors, shows, mainly agonist properties ?-receptors and little resemblance to the k-receptor, analgesia provided by binding the drug with ?-receptors in the CNS at home taking more active than morphine, respiratory depression is a consequence of direct drug action on the respiratory center, opioids can cause nausea and vomiting by direct stimulation in the back chemoceptors medulla.
